Functional Profiling Publications
Functional Profiling Publications

  1. Rines DR, Tu B, Miraglia L, Welch GL, Zhang J, Hull MV, Orth AP, Chanda SK. High-content screening of functional genomic libraries. Methods Enzymol 2006; (In Press).
  2. Mukherji M, Bell R, Supekova L, Wang Y, Orth AP, Batalov S, Miraglia L, Huesken D, Lange J, Martin C, et al. Genome-wide functional analysis of human cell-cycle regulators. Proc Natl Acad Sci U S A 2006;103(40):14819-24.
  3. Luesch H, Chanda SK, Raya RM, DeJesus PD, Orth AP, Walker JR, Izpisua Belmonte JC, Schultz PG. A functional genomics approach to the mode of action of apratoxin A. Nat Chem Biol 2006;2(3):158-67.
  4. Cho CY, Koo SH, Wang Y, Callaway S, Hedrick S, Mak PA, Orth AP, Peters EC, Saez E, Montminy M, et al. Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling. Cell Metab 2006;3(5):367-78.
  5. Agarwal S, Harada J, Schreifels J, Lech P, Nicolai B, Yamaguchi T, Chanda SK, Somia NV. Isolation, characterization and genetic complementation of a cellular mutant resistant to retroviral infection. Proc Natl Acad Sci U S A 2006;103(43):15933-15938.
  6. Liu J, Bang AG, Kintner C, Orth AP, Chanda SK, Ding S, Schultz PG. Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis. Proc Natl Acad Sci U S A 2005;102(6):1927-32.
  7. Li W, Chanda SK, Micik I, Joazeiro CA. Methods for the functional genomic analysis of ubiquitin ligases. Methods Enzymol 2005;398:280-91.
  8. Harada JN, Bower KE, Orth AP, Callaway S, Nelson CG, Laris C, Hogenesch JB, Vogt PK, Chanda SK. Identification of novel mammalian growth regulatory factors by genome-scale quantitative image analysis. Genome Res 2005;15(8):1136-44.
  9. Zeisig BB, Milne T, Garcia-Cuellar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, et al. Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization. Mol Cell Biol 2004;24(2):617-28.
  10. Orth AP, Batalov S, Perrone M, Chanda SK. The promise of genomics to identify novel therapeutic targets. Expert Opin Ther Targets 2004;8(6):587-96.
  11. Huang Q, Raya A, DeJesus P, Chao SH, Quon KC, Caldwell JS, Chanda SK, Izpisua-Belmonte JC, Schultz PG. Identification of p53 regulators by genome-wide functional analysis. Proc Natl Acad Sci U S A 2004;101(10):3456-61.
  12. Chao SH, Harada JN, Hyndman F, Gao X, Nelson CG, Chanda SK, Caldwell JS. PDX1, a cellular homeoprotein, binds to and regulates the activity of human cytomegalovirus immediate early promoter. J Biol Chem 2004;279(16):16111-20.
  13. Chao SH, Walker JR, Chanda SK, Gray NS, Caldwell JS. Identification of homeodomain proteins, PBX1 and PREP1, involved in the transcription of murine leukemia virus. Mol Cell Biol 2003;23(3):831-41.
  14. Chanda SK, White S, Orth AP, Reisdorph R, Miraglia L, Thomas RS, DeJesus P, Mason DE, Huang Q, Vega R, et al. Genome-scale functional profiling of the mammalian AP-1 signaling pathway. Proc Natl Acad Sci U S A 2003;100(21):12153-8.
  15. Chanda SK, Caldwell JS. Fulfilling the promise: drug discovery in the post-genomic era. Drug Discov Today 2003;8(4):168-74.